An idiopathic infertility with oocytes metaphase I maturation block
نویسندگان
چکیده
منابع مشابه
Clinical benefit of metaphase I oocytes
BACKGROUND We studied the benefit of using in vitro matured metaphase I (MI) oocytes for ICSI in patients with a maximum of 6 mature metaphase II (MII) oocytes at retrieval. METHODS In 2004, 187 ICSI cycles were selected in which maximum 6 MII oocytes and at least one MI oocyte were retrieved. MI oocytes were put in culture to mature until the moment of ICSI, which was performed between 2 to ...
متن کاملEffects of sperm insemination on the final meiotic maturation of mouse oocytes arrested at metaphase I after in vitro maturation
OBJECTIVE The aims of this study were to investigate whether fertilization could induce the resumption of meiosis in mouse oocytes arrested at metaphase I (MI) after in vitro maturation (IVM), and to investigate the effect of Ca2+ chelator treatment at the time of fertilization on the transition from MI to metaphase II (MII). METHODS MII-stage and arrested MI-stage mouse oocytes after IVM wer...
متن کاملActivation of Akt (protein kinase B) stimulates metaphase I to metaphase II transition in bovine oocytes.
In somatic cells, the serine/threonine kinase Akt (or protein kinase B) was shown to contribute to processes linked to cellular growth, cell survival and cell cycle regulation. In contrast to these findings, the function of Akt during the meiosis of mammalian oocytes remains to be investigated. We analysed the phosphorylation pattern and the activity of Akt during meiotic maturation (transition...
متن کاملIn vitro maturation, fertilization, embryo development & clinical outcome of human metaphase-I oocytes retrieved from stimulated intracytoplasmic sperm injection cycles
BACKGROUND & OBJECTIVES The major cause of fertilisation failure after ICSI is failure of the oocyte to initiate the biochemical processes necessary for activation. This inability could be ascribed to cytoplasmic immaturity of those gametes even if they had reached nuclear maturity. The activation of a mature oocyte is characterised by release from metaphase II (MII) arrest and extrusion of the...
متن کاملMultiparameter analysis of human oocytes at metaphase II stage after IVF failure in non-male infertility.
BACKGROUND Using fluorescence imaging, an a posteriori multiparametric analysis was performed of human oocytes which failed to give pronucleated zygotes after IVF in cases of very low rates of fertilization or complete fertilization failure. METHODS The analysis included: (i) the state of the maternal and paternal chromatin; (ii) quality of the metaphase II oocytes; and (iii) cortical granule...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2001
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/16.10.2136